【主讲人】Dr. Duojia Pan
The Hippo signaling pathway controls tissue growth, homeostasis and regeneration in diverse animals. In this talk, I will present recent studies into the evolutionary origin of the Hippo pathway and the mechanisms by which upstream regulators of the Hippo pathway integrates diverse physiological inputs into the core kinase cascade.
Duojia (DJ) Pan received a Ph.D. from the University of California, Los Angeles in 1993. After postdoctoral training at the University of California, Berkeley, with Dr. Gerald Rubin, Dr. Pan joined the UT Southwestern faculty as an Assistant Professor of Physiology in 1998 and was promoted to Associate Professor with tenure in 2004. He was recruited to Johns Hopkins that year, and during his time in Baltimore, he was made an HHMI Investigator (2008), a Fellow of the American Association for Advancement of Science (2012), and was awarded the Paul Marks Prize for Cancer Research (2013). In 2016, Dr. Pan returned to UT Southwestern Medical Center as Chairman of the Department of Physiology.
Dr. Pan investigates the molecular mechanisms of growth control and tissue homeostasis. He is best known for pioneering work on the Hippo signaling pathway, an evolutionarily conserved developmental pathway that controls organ size in all animals. His current efforts are aimed at understanding the composition, mechanism and regulation of the Hippo pathway, elucidating its physiological roles in normal development and diseases, and discovery of chemical probes targeting the Hippo pathway.